%0 Journal Article
%T Anterior chest wall inflammation by whole-body magnetic resonance imaging in patients with spondyloarthritis: lack of association between clinical and imaging findings in a cross-sectional study
%A Ulrich Weber
%A Robert GW Lambert
%A Kaspar Rufibach
%A Walter P Maksymowych
%A Juerg Hodler
%A Anna Zejden
%A Stefan Duewell
%A Rudolf O Kissling
%A Paul L Filipow
%A Anne G Jurik
%J Arthritis Research & Therapy
%D 2012
%I BioMed Central
%R 10.1186/ar3551
%X The ACWs of 122 consecutive SpA patients (95 with ankylosing spondylitis (AS) and 27 with nonradiographic SpA (nrSpA)) and 75 healthy controls were scanned by sagittal and coronal WB MRI. The MRI scans were scored independently in random order by seven readers blinded to patient identifiers. Active and structural inflammatory lesions of the ACW were recorded on a web-based data entry form. ACW pain by patient self-report, ACW tenderness on physical examination according to the Maastricht Ankylosing Spondylitis Enthesitis Score (MASES) and lesions detected by MRI were analyzed descriptively. ¦Ê statistics served to assess the agreement between clinical and imaging findings.ACW pain or tenderness was present in 26% of patients, with little difference between AS and nrSpA patients. Bone marrow edema (BME), erosion and fat infiltration were recorded in 44.3%, 34.4% and 27.0% of SpA patients and in 9.3%, 12.0% and 5.3% of controls, respectively. Lesions found by MRI occurred more frequently in AS patients (BME, erosion and fat infiltration in 49.5%, 36.8% and 33.7%, respectively) than in nrSpA patients (25.9%, 25.9% and 3.7%, respectively). The joint most frequently affected by lesions found on MRI scans was the manubriosternal joint. The ¦Ê values between clinical assessments and MRI inflammation ranged from -0.10 to only 0.33 for both AS and nrSpA patients.Among SpA patients, 26% had clinical involvement of the ACW. WB MRI signs of ACW inflammation were found in a substantial proportion of patients with AS (49.5%) and nrSpA (25.9%). There was no association between clinical assessments of ACW, including the MASES, and MRI features.Inflammatory involvement of the anterior chest wall (ACW) has substantial impact on the quality of life of patients with spondyloarthritis (SpA) [1]. However, ACW involvement is often neglected in clinical assessment. Researchers in uncontrolled studies of ACW inflammation who assessed the association between clinical features and various abnor
%U http://arthritis-research.com/content/14/1/R3