%0 Journal Article
%T Lung sonography and recruitment in patients with early acute respiratory distress syndrome: A pilot study
%A Konstantinos Stefanidis
%A Stavros Dimopoulos
%A Elli-Sophia Tripodaki
%A Konstantinos Vitzilaios
%A Panagiotis Politis
%A Ploutarchos Piperopoulos
%A Serafim Nanas
%J Critical Care
%D 2011
%I BioMed Central
%R 10.1186/cc10338
%X Ten patients (mean ¡À standard deviation (SD): age 64 ¡À 7 years, Acute Physiology and Chronic Health Evaluation II (APACHE II) score 21 ¡À 4) with early ARDS on mechanical ventilation were included in the study. Transthoracic sonography was performed in all patients to depict the nonaerated area in the dependent lung regions at different PEEP settings of 5, 10 and 15 cm H2O. Lung sonographic assessment of the nonaerated lung area and arterial blood gas analysis were performed simultaneously at the end of each period. A control group of five early ARDS patients matched for APACHE II score was also included in the study.The nonaerated areas in the dependent lung regions were significantly reduced during PEEP increases from 5 to 10 to 15 cm H2O (27 ¡À 31 cm2 to 20 ¡À 24 cm2 to 11 ¡À 12 cm2, respectively; P < 0.01). These changes were associated with a significant increase in arterial oxygen partial pressure (74 ¡À 15 mmHg to 90 ¡À 19 mmHg to 102 ¡À 26 mmHg; P < 0.001, respectively). No significant changes were observed in the nonaerated areas in the dependent lung regions in the control group.In this study, we show that transthoracic lung sonography can detect the nonaerated lung area changes during a PEEP trial of patients with early ARDS. Thus, transthoracic lung sonography might be considered as a useful clinical tool in the management of ARDS patients.Acute respiratory distress syndrome (ARDS) is a clinical syndrome that often occurs in critically ill patients. It is a nonspecific response of the lung to injury due to a pulmonary or extrapulmonary insult. Specifically, it is characterized by the presence of diffuse lung inflammation, high permeability-type pulmonary oedema and massive loss of lung aeration in dependent lung regions and is associated with severe hypoxemia and a high mortality rate [1-3].Patients with ARDS invariably require mechanical ventilation to decrease the work of breathing and to improve oxygen transport. An improvement in oxygenation can be obtained
%U http://ccforum.com/content/15/4/R185