%0 Journal Article
%T Increased liver regeneration rate and decreased liver function after synchronous liver and colon resection in rats
%A Hideki Sasanuma
%A Frank Mortensen
%A Anders Knudsen
%A Peter Funch-Jensen
%A Masaki Okada
%A Hideo Nagai
%A Yoshikazu Yasuda
%J Annals of Surgical Innovation and Research
%D 2009
%I BioMed Central
%R 10.1186/1750-1164-3-16
%X Ninety-six Sprague-Dawley rats were block-randomized into six groups: Group I had a laparotomy performed. Group II had 1 cm colon resected and anastomosed. Group III and V had 40% or 70% of the liver resected, respectively. Additionally Group IV and VI had 1 cm colon resected and anastomosed, respectively. Body weight was recorded on postoperative day 0, 3, 5 and 7. Rats were sacrificed on postoperative day 7 by rapid collection of blood from the inferior vena cava, and endotoxin levels were measured. Remnant liver function was evaluated by means of branched amino acids to tyrosine ratio. Liver regeneration was calculated by (liver weight per 100 g of the body weight at sacrifice/preoperative projected liver weight per 100 g of the body weight) กม 100.The total number of complications was significantly higher in Group VI than Group I, III, IV, and V. Body weight and branched amino acids to tyrosine ratio were both significantly lower in rats that had simultaneous colonic and liver resection performed. Hepatic regeneration rate was significantly higher in the simultaneous colectomy group. Systemic endotoxin levels were unaffected by simultaneous colectomy on postoperative day 7.In our model morbidity seems to be related to the extent of hepatic resection. In rats undergoing liver resection, simultaneous colectomy induced a higher degree of hepatic regeneration rate. Body weight changes and branched amino acids to tyrosine ratio were negatively affected by simultaneous colectomy.Surgical resection of colorectal liver metastases offers the best possibility for long-term survival. After complete resection of detectable metastases, about one third of patients survive for at least 5 years [1,2]. The surgical strategy for the treatment of colorectal cancer and synchronous liver metastases remains controversial. Simultaneous colorectal and liver resections might impose an increased risk of postoperative liver dysfunction and septic complications [3-5]. In a previous study, w
%U http://www.asir-journal.com/content/3/1/16