%0 Journal Article
%T Correlation between antibutyrylcholinesterasic and antioxidant activities of three aqueous extracts from Tunisian Rhus pentaphyllum
%A Hedi Mansour
%A Sonia Yatouji
%A Sihem Mbarek
%A Ikram Houas
%A Afef Delai
%A Dorra Dridi
%J Annals of Clinical Microbiology and Antimicrobials
%D 2011
%I BioMed Central
%R 10.1186/1476-0711-10-32
%X The present study indicates that extracts of Rhus pentaphyllum leaves, seeds and roots are a significant source of compounds, such as tannins, flavonoids and coumarins, with anti-BuChE and antioxidant activities, and thus may be useful for chemoprevention.Alzheimer's disease (AD) is a degenerative neurological disorder characterized by senile plaques containing amyloid ¦Â protein and loss of cholinergic neuromediators in the brain [1,2]. The most remarkable biochemical change in AD patients is a reduction of acetylcholine (ACh) levels in the hippocampus and cortex of the brain [3]. Therefore, inhibition of acetylcholinesterase (AChE), the enzyme responsible for hydrolysis of ACh at the cholinergic synapse, is currently the most established approach to treating AD [4]. While AChE is found in all excitable tissue, whether nerve or muscle, in most erythrocytes and in placental tissue, BChE is present more commonly in the body including the central and peripheral nervous system, liver and plasma [5]. On the other hand, oxidative stress caused by reactive oxygen species (ROS), is known to cause the oxidation of biomolecules leading to cellular damage. It is also speculated to be pathologically important in various neurodegenerative processes including cognitive deficits that occur during normal cerebral aging, Alzheimer's disease (AD) and Parkinson's disease [6-8]. Nowadays, the most accepted theory about the disturbing effect of free radicals in the process of aging was reported by Harman [9]. Later on, it was also reported that oxidative stress is associated with the pathogenesis of AD and cellular characteristics of this disease are either causes or effects of oxidative stress [10,11].These evidences clearly show that oxidative stress, an early event in AD, may play a key pathogenic role in the disease [12]. Interestingly, intake of polyphenols through diets rich in fruits, vegetables and beverages such as red wine was stated to reduce incidence of certain age related
%K Rhus pentaphyllum
%K anti-Butyrylcholinesterasic activity
%K free radical scavenging activity
%K antioxidant activity
%U http://www.ann-clinmicrob.com/content/10/1/32