%0 Journal Article
%T Allosteric transition. A comparison of two models
%A Niels Bindslev
%J BMC Pharmacology and Toxicology
%D 2013
%I BioMed Central
%R 10.1186/2050-6511-14-4
%X I show here that Hall's model for interactions between an orthoster, an alloster, and a receptive unit is the best choice of model both for simulation and analysis of allosteric concentration-responses at equilibrium or steady-state.As detailed knowledge of receptors systems becomes available, systems with several pathways and states and/ or more than two binding sites should be analysed by extended forms of the Hall model rather than for instance a Hill type exponentiation of terms as introduced in non-mechanistic (operational) model approaches; yielding semi-quantitative estimates of actual system parameters based on Hill's unlikely simultaneity model for G protein-coupled receptors.
%U http://www.biomedcentral.com/2050-6511/14/4/abstract