%0 Journal Article
%T Serum tumor markers in pediatric osteosarcoma: a summary review
%A Yulia A Savitskaya
%A Genaro Rico-Mart¨ªnez
%A Luis Miguel Linares-Gonz¨¢lez
%A Ernesto Andr¨¦s Delgado-Cedillo
%A Ren¨¦ T¨¦llez-Gastelum
%A Alfonso Benito Alfaro-Rodr¨ªguez
%A Antonio Red¨®n-Tavera
%A Jos¨¦ Clemente Ibarra-Ponce de Le¨®n
%J Clinical Sarcoma Research
%D 2012
%I BioMed Central
%R 10.1186/2045-3329-2-9
%X Most of the studies have examined the association of a serum marker with some aspect of the natural history of pediatric osteosarcoma. As illustrated by the many studies reviewed, several serum markers are emerging that show a credible association with disease modification. The expanding pool of informative osteosarcoma-related markers is expected to impact development of therapeutics for pediatric osteosarcoma positively and, it is hoped, ultimately clinical care. Combinations of serum markers of natural immunity, thyroid hormone homeostasis, and bone tumorigenesis may be undertaken together in patients with pediatric osteosarcoma. These serum markers in combination may do better. The potential effect of an intrinsic dynamic balance of tumor angiogenesis residing within a single hormone (tri-iodothyronine) is an attractive concept for regulation of vascularization in pediatric osteosarcoma.Osteosarcoma is the most prevalent malignant bone tumor [1]. Accounting for 30%-80% of the primary skeletal sarcomas, it is the most common of all bone malignancies [2]. The population affected is predominantly children, teenagers, and young adults aged 10-30 years [3]. Males are more affected than females. Osteosarcomas predominantly target the long cylindrical bones, including the knee joint (approximately half of the observations) and the humerus [4]. Among the most affected are the femur, tibia, and humerus. The tumor is less frequently localized in the shoulder blade, pelvic, and skull bones [5]. Typically, osteogenetic sarcomas metastasize early into the lungs, and metastases to lymph nodes are found in isolated cases [6,7].Today's leading researchers, pharmacy and biotechnology decision-makers, technology companies, and clinicians are focusing on the use of serum tumor markers in the field of pediatric osteosarcoma research. The search for serum tumor markers for early detection and diagnosis of pediatric osteosarcoma has been a daunting task which has been met with little
%K pediatric osteosarcoma
%K serum tumor markers
%K natural immunity
%K thyroid hormone homeostasis
%K bone tumorigenesis
%U http://www.clinicalsarcomaresearch.com/content/2/1/9