%0 Journal Article
%T Vaginal metastasis of a Ewing sarcoma five years after resection of the primary tumor
%A Noemie Vanel
%A Victoire Vierling
%A Jennifer Kreshak
%A Marco Gambarotti
%A Stefania Cocchi
%A Cristina Tranfaglia
%A Daniel Vanel
%J Clinical Sarcoma Research
%D 2011
%I BioMed Central
%R 10.1186/2045-3329-1-9
%X To our knowledge, this is the first reported case of a vaginal metastasis of Ewing sarcoma.Ewing sarcoma (ES) is a small blue round cell tumor belonging to the Ewing Family Tumour (EFT) together with Primary Neuroectodermal Tumour (PNET) and ASKIN tumor (of the thoracic wall). Eight hundred and ninety six cases have been reported in our institute since 1982. Ewing sarcoma has a distinct predilection for males and occurs in the first two decades of life in more than 75 percent of cases [1,2].Metastases are frequent [3] and are mostly pulmonary and osseous, but can be found in various other locations.We present here the first description of a vaginal metastasis of Ewing sarcoma.A 35 year-old woman with no significant medical history presented with pain and swelling of the left wrist over the past year. A radiograph and computed tomography scan revealed a lytic lesion of the distal left radius (Figure 1), with soft tissue extension on MR examination (Figure 2, 3).A biopsy was performed and histological examination revealed a typical Ewing sarcoma. The diagnosis was confirmed by FISH analysis, which demonstrated the translocation t (11, 22).Staging revealed a solitary non-specific pulmonary nodule of the inferior right lobe that did not change with time and was not considered metastatic.The patient underwent neoadjuvant chemotherapy and resection and allograft of the distal radius. She was considered as poor responder as macroscopic areas remained on the surgical specimen, but all margins were free of disease. High dose chemotherapy was then performed.After completion of her treatment, it was followed up as per protocol and remained disease-free.Five years later, during a routine gynaecologic exam, a vaginal polyp was found and removed. Histology revealed a ES metastasis (Figure 4), as confirmed by the characteristic translocation t(11, 22).(Figure 5). The rest of the evaluation (CT and bone scintigraphy) was normal.No treatment has been undertaken.Ewing sarcoma (ES) re
%K Ewing sarcoma
%K vaginal metastasis
%U http://www.clinicalsarcomaresearch.com/content/1/1/9