%0 Journal Article
%T Outcome following patent ductus arteriosus ligation in premature infants: a retrospective cohort analysis
%A LLeona CL Lee
%A Angela Tillett
%A Robert Tulloh
%A Robert Yates
%A Wilf Kelsall
%J BMC Pediatrics
%D 2006
%I BioMed Central
%R 10.1186/1471-2431-6-15
%X A retrospective case note review study to determine the outcome of premature infants undergoing patent ductus arteriosus ligation in one tertiary neonatal intensive care unit and two paediatric cardiothoracic centres.We had follow-up data on 87 infants. Cumulative mortality rates at 7 days, 30 days and at hospital discharge were 2%, 8% and 20% respectively. The incidence of chronic lung disease, intraventricular haemorrhage, necrotising enterocolitis and retinopathy of prematurity were 77%, 39%, 26% and 28% respectively. There was no difference in mortality, incidence of chronic lung disease or duration of oxygen dependence between those who had and those who had not received a PSI prior to surgical ligation. In those who had received 2 or more courses of PSI prior to surgical ligation, there was a trend to increase in the duration of oxygen therapy and chronic lung disease, but no difference in mortality.This study shows that patent ductus arteriosus ligation is a relatively safe procedure (30 day survival 92%) but there is substantial late mortality and a high incidence of morbidity in the survivors. 2 or more courses of PSI prior to surgical ligation trends to increased oxygen dependence and chronic lung disease. This high risk population requires careful follow-up. A definitive prospective cohort study is lacking.The patent ductus arteriosus (PDA) is an important problem in premature infants [1]. Left to right shunting through the PDA results in increased pulmonary blood flow and steal from the systemic circulation. These haemodynamic changes may be responsible for the co-morbid conditions associated with a PDA: prolonged ventilator dependence and chronic lung disease (CLD) [2], pulmonary haemorrhage (PH) [3], intraventricular haemorrhage (IVH) [4], necrotising enterocolitis (NEC) [5] and retinopathy of prematurity (ROP) [6]. Neonatologists may use a variety of first line strategies to close a PDA in a symptomatic preterm infant, including careful fluid administ
%U http://www.biomedcentral.com/1471-2431/6/15