%0 Journal Article
%T Exploring the temporal development of childhood IgE profiles to allergen components
%A Annica £¿nell
%A Lisbeth Hj£¿lle
%A Magnus P Borres
%J Clinical and Translational Allergy
%D 2012
%I BioMed Central
%R 10.1186/2045-7022-2-24
%X The aim was to study the sensitization pattern to allergen components over time from infancy to adulthood in a group of infants with heredity for allergic diseases.IgE profiles were monitored in a group of 67 children from 6 months to 18 years using a microarray chip (ImmunoCAP£¿ ISAC) containing 103 allergen components derived from 47 allergen sources. The chip IgE profile was compared with clinical history, skin prick test results and diagnoses (atopic dermatitis, asthma and allergic rhinoconjunctivitis) at each time point for each child.IgE profiles were unique for each child and showed broad agreement with the results of skin prick tests and doctors¡¯ diagnoses. In addition, close examination of the IgE profiles often revealed early indication of subsequent allergies. IgE profiles also facilitated the examination of cross-reactivity contra co-sensitization, thereby greatly enhancing the possibility for managing patients.This explorative description indicates that sensitization pattern to allergen components differs over time as well as among allergic individuals when examined with microarray technology.Atopic disease is one of the most common chronic disorders worldwide among both children and adults. The term ¡°atopic march¡± refers to the dynamic process of manifestation, persistence, and remission of different atopic phenotypes in the first two decades of life [1,2]. Atopic dermatitis per se does not constitute a risk for asthma, but may do so when associated with allergic sensitization [3]. Persistent asthma is more likely in children with early sensitization to indoor allergens and exposure.Objective measurement of atopic status, including quantification of markers of sensitization, is needed to quantify asthma risk [3,4]. Recent research has identified some useful indicators of potential allergy manifestation. These indicators include family history of asthma and allergies, early, multiple and severe sensitization to some food- and aeroallergens, and early vir
%K Children
%K Atopic march
%K Specific IgE
%K ImmunoCAP ISAC
%K CRD
%K Allergen components
%U http://www.ctajournal.com/content/2/1/24