%0 Journal Article
%T Relationship of metabolic syndrome and its components with -844 G/A and HindIII C/G PAI-1 gene polymorphisms in Mexican children
%A Ulises De la Cruz-Mosso
%A Jos¨¦ F Mu£¿oz-Valle
%A Lorenzo Salgado-Goytia
%A Adri¨¢n Garc¨ªa-Carre¨®n
%A Berenice Illades-Aguiar
%A Eduardo Casta£¿eda-Saucedo
%A Isela Parra-Rojas
%J BMC Pediatrics
%D 2012
%I BioMed Central
%R 10.1186/1471-2431-12-41
%X This study included 100 children with an age range between 6-11 years divided in two groups: a) 48 children diagnosed with metabolic syndrome and b) 52 children metabolically healthy without any clinical and biochemical alteration. Metabolic syndrome was defined as the presence of three or more of the following criteria: fasting glucose levels ¡İ 100 mg/dL, triglycerides ¡İ 150 mg/dL, HDL-cholesterol < 40 mg/dL, obesity BMI ¡İ 95th percentile, systolic blood pressure (SBP) and diastolic blood pressure (DBP) ¡İ 95th percentile and insulin resistance HOMA-IR ¡İ 2.4. The -844 G/A and HindIII C/G PAI-1 polymorphisms were analyzed by PCR-RFLP.For the -844 G/A polymorphism, the G/A genotype (OR = 2.79; 95% CI, 1.11-7.08; p = 0.015) and the A allele (OR = 2.2; 95% CI, 1.10-4.43; p = 0.015) were associated with metabolic syndrome. The -844 G/A and A/A genotypes were associated with increase in plasma triglycerides levels (OR = 2.6; 95% CI, 1.16 to 6.04; p = 0.02), decrease in plasma HDL-cholesterol levels (OR = 2.4; 95% CI, 1.06 to 5.42; p = 0.03) and obesity (OR = 2.6; 95% CI, 1.17-5.92; p = 0.01). The C/G and G/G genotypes of the HindIII C/G polymorphism contributed to a significant increase in plasma total cholesterol levels (179 vs. 165 mg/dL; p = 0.02) in comparison with C/C genotype.The -844 G/A PAI-1 polymorphism is related with the risk of developing metabolic syndrome, obesity and atherogenic dyslipidemia, and the HindIII C/G PAI-1 polymorphism was associated with the increase of total cholesterol levels in Mexican children.Metabolic syndrome (MetS) is a common disorder caused by a combination of poor diet, sedentary lifestyle and genetic predisposition [1], the presence of MetS in children is the main risk factor that predisposes to the development of cardiovascular and metabolic diseases such as atherosclerosis and type 2 diabetes mellitus in adulthood [2]. The components of MetS include obesity, insulin resistance, hyperglycemia, atherogenic dyslipidemia, and hyperte
%K Metabolic syndrome
%K PAI-1
%K Polymorphism
%K Dyslipidemia
%K Children
%U http://www.biomedcentral.com/1471-2431/12/41