%0 Journal Article
%T High-molecular-weight adiponectin and anthropometric variables among elementary schoolchildren: a population-based cross-sectional study in Japan
%A Hirotaka Ochiai
%A Takako Shirasawa
%A Rimei Nishimura
%A Aya Morimoto
%A Tadahiro Ohtsu
%A Hiromi Hoshino
%A Naoko Tajima
%A Akatsuki Kokaze
%J BMC Pediatrics
%D 2012
%I BioMed Central
%R 10.1186/1471-2431-12-139
%X Subjects comprised all fourth-grade schoolchildren (9 or 10 years of age) in the town of Ina, Saitama Prefecture, Japan during 2005¨C2008 (N£¿=£¿1675). After excluding 21 subjects because of refusal to participate or incomplete data, data from a total of 1654 subjects (846 boys and 808 girls) were analyzed. The height, weight, %BF, and WC of each subject were measured, while blood samples were drawn from the subjects to measure adiponectin levels (HMW-adn and total adiponectin). Childhood obesity was determined according to the age- and sex-specific cut-off points proposed by the International Obesity Task Force. Spearman¡¯s correlation coefficients between adiponectin levels and anthropometric variables were calculated for each sex.The anthropometric variables were negatively correlated with HMW-adn in both boys and girls. Correlation coefficients of HMW-adn with anthropometric variables in the obesity group were consistently higher than those in the non-obesity group among both boys and girls. In addition, only WHtR was significantly correlated with HMW-adn regardless of sex and physique (obesity or non-obesity); the correlation coefficient was -0.386 among boys and -0.543 among girls in the obesity group, while it was -0.124 among boys and -0.081 among girls in the non-obesity group.HMW-adn was negatively correlated with anthropometric variables, while the correlation coefficients of HMW-adn with anthropometric variables in the obesity group were consistently higher than those in the non-obesity group. Moreover, only WHtR was significantly associated with HMW-adn regardless of sex and physique. The results of this study suggested that it is useful to monitor WHtR as a surrogate for HMW-adn among elementary school students, especially obese children.Adiponectin is an adipocyte-derived secretory protein that has been very widely studied over the past 15 years [1]. Adiponectin exists as multimers in serum and high-molecular-weight adiponectin (HMW-adn) is particularly c
%K High-molecular-weight adiponectin
%K Anthropometric variable
%K Obesity
%K Waist-to-height ratio
%K Children
%U http://www.biomedcentral.com/1471-2431/12/139