%0 Journal Article
%T Renal histomorphology in dogs with pyometra and control dogs, and long term clinical outcome with respect to signs of kidney disease
%A Reidun Heiene
%A Veronica Kristiansen
%A Jon Teige
%A Johan Jansen
%J Acta Veterinaria Scandinavica
%D 2007
%I BioMed Central
%R 10.1186/1751-0147-49-13
%X Dogs with pyometra were examined retrospectively for evidence of secondary renal damage and persisting renal disease through two retrospective studies. In Study 1, light microscopic lesions of renal tissue were graded and compared in nineteen dogs with pyometra and thirteen age-matched control bitches. In Study 2, forty-one owners of dogs with pyometra were interviewed approximately 8 years after surgery for evidence ofclinical signs of renal failure in order to document causes of death/euthanasia.Interstitial inflammation and tubular atrophy were more pronounced in dogs with pyometra than in the control animals. Glomerular lesions classified as glomerular sclerosis were present in both groups. No unequivocal light microscopic features of glomerulonephritis were observed in bitches in any of the groups.Two bitches severely proteinuric at the time of surgery had developed end stage renal disease within 3 years. In five of the bitches polyuria persisted after surgery. Most bitches did not show signs of kidney disease at the time of death/euthanasia.Tubulointerstitial inflammation was observed, but glomerular damage beyond age-related changes could not be demonstrated by light microscopy in the dogs with pyometra. However, severe proteinuria after surgery may predispose to development of renal failure.In both human [1] and veterinary nephrology [2,3]., proteinuria has been shown to contribute substantially to the development of end stage renal disease. Clinical intervention by drug therapy is indicated to protect renal function [4].Proteinuria is the hallmark of glomerular disease. Polyuria, polydipsia (PU/PD), proteinuria and azotemia are common features of canine pyometra [5-10]. Because polyuria/polydipsia usually disappear after treatment, the accompanying renal lesions are described as temporary. The renal pathology and long term clinical outcome in dogs with pyometra is poorly defined. Controversy exists as to whether pathological findings indicative of a tubuloi
%U http://www.actavetscand.com/content/49/1/13