%0 Journal Article
%T Influence of Mobile Phase Composition on Chiral Separation of Albendazole Sulfoxide Racemates<br>流动相组成对外消旋阿苯达唑亚砜对映体拆分的影响
%A ZHAI Zongde~
%A ZHANG Hong~
%A DUN Huijuan~
%A LIU Chunhui~
%A CHEN Liren~
%A LI Yongmin~
%A <br>翟宗德
%A 张虹
%A 敦惠娟
%A 柳春辉
%A 陈立仁
%A 李永民
%J 色谱
%D 2004
%I 
%X A chiral stationary phase (CSP) was prepared by coating amylose-tris ( 3,5-dimethylphenyl carbamate ) (ADMPC) onto aminopropylated spherical silica gel. Albendazole sulfoxide (ABZSO) was directly resolved on the ADMPC-CSP by normal-phase high performance (liquid) chromatography (HPLC) using a series of binary and ternary mobile phases. The results (indicated) that the retention and stereoselectivity of ABZSO on ADMPC-CSP were significantly (influenced) by the kinds and the contents of the alcohols in mobile phases. The use of methanol and/or ethanol as alcoholic modifier achieved better separation of ABZSO. Effective and efficient chiral resolution was obtained by using ternary mobile phases: hexane/2-propanol/methanol or hexane/ethanol/methanol.
%K high performance liquid chromatography
%K chiral separation
%K alcoholic modifier
%K (albendazole) sulfoxide
%K amylose-tris (3
%K 5-dimethylphenyl carbamate)<br>高效液相色谱法
%K 手性拆分
%K 醇类改性剂
%K 阿苯达唑亚砜
%K 直链淀粉-三（3，5-二甲基苯基氨基甲酸酯）
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=6E709DC38FA1D09A4B578DD0906875B5B44D4D294832BB8E&cid=6579068328FE643F&jid=4D81E042D77AFEC6881D14759692069C&aid=D7452E4481EEB209&yid=D0E58B75BFD8E51C&vid=BC12EA701C895178&iid=38B194292C032A66&sid=5B5B75F4854B8331&eid=002786F01A86D891&journal_id=1000-8713&journal_name=色谱&referenced_num=2&reference_num=11