%0 Journal Article
%T The Enantiomeric Separation of Aromatic Alcohol Amino Drugs by Thin-Layer Chromatography<br>用薄层色谱法分离芳香醇胺药物对映体
%A Li Gaolan
%A Huang Mubin
%A Yang Guosheng
%A Wu Guowei
%A Du Aiqin
%A <br>李高兰
%A 黄慕斌
%A 杨国生
%A 吴国伟
%A 杜爱琴
%A 苏燕生
%J 色谱
%D 1999
%I 
%X Two chiral aromatic alcohol amino drugs, Labarol and Bataroc, were resolved by thinlayer chromatography (TLC) on the silica gel GF254 plates (2.5 cm x 10 cm), by using the ammonium-D-10-camphorsulfonate (CSA) as chiral ion-pair interaction agent which was added to the mobile phase in the ammonium form. All developments were carried out at lower temperature (2-4 degrees C, in a refrigerator) in small glass jars of 250 mL volume. These two drugs were not resolved at room temperature (15-30 degrees C). Analytical reagent grade methanol and dichloromethane can be directly used as mobile phase without further drying. The chiral separation occured over a range from 40% to 70% (optimum 67%) dichloromethane in the mobile phase volume ratio and 55% to 80% (optimum 60%) dichloromethane in the mobile phase volume ratio. These separation conditions were easily obtained. This method is relatively inexpensive and attractive.
%K thin-layer chromatography
%K chiral ion-pair agent
%K enantiomer separation
%K aromatic alcohol amine<br>薄层色谱法
%K 手性离子对试剂
%K 对映体分离
%K 芳香醇胺
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=6E709DC38FA1D09A4B578DD0906875B5B44D4D294832BB8E&cid=6579068328FE643F&jid=4D81E042D77AFEC6881D14759692069C&aid=D7F5F79B7B81B862A24B5CB8E1DE2BD9&yid=B914830F5B1D1078&vid=BCA2697F357F2001&iid=0B39A22176CE99FB&sid=1B64850025D0BBBE&eid=CEC789B3C68C3BB3&journal_id=1000-8713&journal_name=色谱&referenced_num=4&reference_num=1