%0 Journal Article
%T Determination of Iohexol by High Performance Liquid Chromatography<br>高效液相色谱法测定非离子造影剂欧乃帕克
%A ZHU Qiuyu
%A GU Yong
%A DING Feng
%A LIN Shantan
%A <br>朱秋毓
%A 顾勇
%A 丁峰
%A 林善锬
%J 色谱
%D 2004
%I 
%X A fast, sensitive and reproducible method for the determination of iohexol by high performance liquid chromatography with narrow-bore column was developed. The method involved one step deproteinization of plasma by perchloric acid and a simple, isocratic elution system of 7% (v/v) methane solution. The linearity of the method ranged from 0.5 to 500 mg/L of iohexol with a correlation coefficient of more than 0.999 8. Minimum detection limit was 154 pg of the agent in plasma. Retention time for the contrast medium in the elution system was (3.46 +/- 0.02) min and a single run was less than 5 min. The relative standard deviation of iohexol in peak area was less than 4.3% for run to run within a day and 11.4% for day to day operations. The recoveries of iohexol in plasma were over 91.51% at low, middle and high concentrations.
%K high performance liquid chromatography
%K narrow-bore column
%K non-ionic contrast medium
%K iohexol<br>非离子造影剂
%K 欧乃帕克
%K 高效液相色谱法
%K 测定
%K 肾小球滤过率
%K 细径柱
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=6E709DC38FA1D09A4B578DD0906875B5B44D4D294832BB8E&cid=6579068328FE643F&jid=4D81E042D77AFEC6881D14759692069C&aid=87FD5C4A5DD783F6&yid=D0E58B75BFD8E51C&vid=BC12EA701C895178&iid=CA4FD0336C81A37A&sid=933658645952ED9F&eid=42425781F0B1C26E&journal_id=1000-8713&journal_name=色谱&referenced_num=0&reference_num=10