%0 Journal Article
%T Direct Enantiomeric Separation of Pantoprazole Sodium by High Performance Liquid Chromatography<br>高效液相色谱法直接拆分泮托拉唑钠对映体
%A DING Guosheng
%A CONG Runzi
%A WANG Junde
%A <br>丁国生
%A 丛润滋
%A 王俊德
%J 色谱
%D 2004
%I 
%X By using the Kromasil CHI-TBB chiral stationary phase, the racemic mixture of pantoprazole sodium was resolved in the normal phase mode. The influences of the composition of the mobile phase, the content of acidic and basic additives and the flow rate on this enantiomer separation were studied. The chiral high performance liquid chromatographic method for the analysis of pantoprazole sodium was established with high efficiency and good repeatability, by using hexane-isopropanol-acetic acid mixture (95:5:0.1, v/v) as the mobile phase at a flow rate of 2.0 mL/min at 25 degrees C.
%K high performance liquid chromatography
%K chiral stationary phase
%K pantoprazole sodium enantiomers
%K chiral separation<br>高效液相色谱法
%K 手性固定相
%K 泮托拉唑钠埘映体
%K 手性分离
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=6E709DC38FA1D09A4B578DD0906875B5B44D4D294832BB8E&cid=6579068328FE643F&jid=4D81E042D77AFEC6881D14759692069C&aid=F7BA7ED5BEFA090A&yid=D0E58B75BFD8E51C&vid=BC12EA701C895178&iid=38B194292C032A66&sid=6A73B36E85DB0CE9&eid=B78CD622C1934236&journal_id=1000-8713&journal_name=色谱&referenced_num=1&reference_num=8