%0 Journal Article
%T Separation and determination of naproxen by reversed-phase high performance liquid chromatography]<br>反相键合相高效液相色谱法分离测定萘普生
%A C Wang
%A G Zou
%A <br>王丛香
%A 邹公伟
%J 色谱
%D 1998
%I 
%X A reversed-phase HPLC method has been developed for the separation and determination of naproxen and its bromo-substituted compound. These compounds were separated on a Shim-pack CLC ODS column (5 microns, 250 mm x 4.6 mm i.d.) by using a methanol-water (80/20, V/V) solution containing 50 mmol/L lactic acid and adjusted to pH 2.5 with perchloric acid as mobile phase, with flow rate of 0.8 mL/min and UV detection at 271 nm. Benzoic acid was selected as an internal standard. At the concentration range of 5-100 mg/L, the linear internal standard working curves with r > 0.9995 were obtained. The accuracy of this method for naproxen and its bromo-substituted compound were 99.83%-102.07% and 99.00%-100.83%, and RSD were < 2.58% and < 3.64% respectively.
%K NULL<br>高效液相色谱
%K 键合相
%K 萘谱生
%K 固定相
%K 分离
%K 分析
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=6E709DC38FA1D09A4B578DD0906875B5B44D4D294832BB8E&cid=6579068328FE643F&jid=4D81E042D77AFEC6881D14759692069C&aid=F65B1163FA62F63D6A77AEB227021FC4&yid=8CAA3A429E3EA654&vid=7801E6FC5AE9020C&iid=38B194292C032A66&sid=627456E7977439A4&eid=4290346F7268639E&journal_id=1000-8713&journal_name=色谱&referenced_num=0&reference_num=0