%0 Journal Article
%T Preparation of Covalently Bonded Cellulose Tris (4-Methyl-benzoate) Derivative Chiral Stationary Phases Through a Polymerization Reaction<br>聚合反应制备键合型纤维素-三(4-甲基苯基甲酸酯)衍生物类手性固定相
%A QIN Feng
%A CHEN Xiaoming
%A LIU Yueqi
%A KONG Liang
%A ZOU Hanfa
%A <br>秦峰
%A 陈小明
%A 刘月启
%A 孔亮
%A 邹汉法
%J 色谱
%D 2004
%I 
%X Cellulose tris (4-methylbenzoate) derivatives (CTMB) having methacryloyl groups were synthesized with regio-selective or nonselective procedures, and were immobilized on gamma-methacrylatepropylated silica (gamma-MAPS) through a polymerization reaction. The obtained chiral stationary phases ( CSPs) were evaluated by high performance liquid chromatographic (HPLC) resolution of 9 racemates (3-butyl-phthalide, ketoprofen, trans-stilbene oxide, benzoin, benzoin analogue, Tr?ger' s base, warfarin, 4,4'-dimethoxy-5,6,5',6'-dimethylenedioxy-biphenyl-2,2'-dicarboxylate and 4,4'-dimethoxy-5,6,5',6'-dimethylenedioxy-biphenyl-2-methylcarboxylate-2'-ethylcarboxylate). For regio-nonselective procedure, increasing the content of vinyl group on CTMB would lead to higher immobilization efficiency and enantio-selectivity. CSPs prepared by regio-selective procedure possessed slightly higher enantioselectivities than those prepared by regio-nonselective procedure, while the latter showed some advantages for rapid and facile preparation. CSPs prepared with silica gel II (Fuji, 5 microm, 30 nm, ca. 150 m2/g) showed higher enantioselectivities than those prepared with silica gel I (Kromasil, 5 microm, 20 nm, ca. 240 m2/g). The prepared CSPs could keep stable under different eluents, even with 40% of tetrahydrofuran (THF) in mobile phases.
%K cellulose tris (4-methylbenzoate) derivatives
%K chemical bonding
%K chiral stationary phase
%K chiral separation<br>纤维素三(4-甲基苯基甲酸酯)衍生物
%K 键合
%K 手性固定相
%K 手性分离
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=6E709DC38FA1D09A4B578DD0906875B5B44D4D294832BB8E&cid=6579068328FE643F&jid=4D81E042D77AFEC6881D14759692069C&aid=0728574A64943954&yid=D0E58B75BFD8E51C&vid=BC12EA701C895178&iid=B31275AF3241DB2D&sid=1FA4E9C3E6E88FC8&eid=F6467E7C54ED952D&journal_id=1000-8713&journal_name=色谱&referenced_num=3&reference_num=15