%0 Journal Article
%T Determination of Ibandronate by High Performance Ion Exchange Chromatography<br>高效离子交换色谱法测定埃本膦酸钠
%A HU Ming-yang
%A ZHOU Xing-qin
%A WANG Bo-cheng
%A <br>胡名扬
%A 周杏琴
%A 王博诚
%J 色谱
%D 2000
%I 
%X A method for the determination of Ibandronate by high performance ion exchange chromatography is reported.Ibandronate can form a complex compound with the copper ion added in the mobile phase.The complex can be detected at UV 240 nm.The effects of pH of mobile phase and concentration of methanol to the retention time wrer studied.Concentration of 10% methanol and pH 2.5 wre suitable for the detection in less than 5min.The flow rate was 1.0 mL/min.The relative standard deviation of peak area was 0.8%.The linear correlation was observed from 300 mg/L to 1 500mg/L of Ibandronate (r=0.998 9).The lowest detectable concentration of Ibandronate was 6 mg/l.The method is simple,rapid and reproducible.
%K high performance ion exchange chromatography
%K Ibandronate
%K complex<br>离子交换色谱法
%K 埃本膦酸钠
%K 测定
%K 骨质疏松症
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=6E709DC38FA1D09A4B578DD0906875B5B44D4D294832BB8E&cid=6579068328FE643F&jid=4D81E042D77AFEC6881D14759692069C&aid=9BA2AC08419A7FD8CEAE2CA76FBEF333&yid=9806D0D4EAA9BED3&vid=13553B2D12F347E8&iid=38B194292C032A66&sid=01622E3E475F966C&eid=627456E7977439A4&journal_id=1000-8713&journal_name=色谱&referenced_num=3&reference_num=1