%0 Journal Article
%T The separation of three basic drugs with carboxymethyl-poly-beta-cyclodextrin as chiral additive by capillary electrophoresis]<br>用羧甲基聚合环糊精作手性剂的毛细管电泳法分离3种碱性药物
%A FAN Rui fang
%A SHI Xue yan
%A GU Jun ling
%A DENG Yu lin
%A FU Ruo nong
%A <br>范瑞芳
%A 史雪岩
%A 顾峻岭
%A 邓玉林
%A 傅若农
%J 色谱
%D 2000
%I 
%X Five cyclodextrin derivatives, namely phosphate ester beta-CD, carboxymethyl-beta-CD(CM-beta-CD), bis-6-oxygen-(beta-carboxymethyl-succinic acid-4-ester)] beta-CD(F-CM-beta-CD), beta-CD polymer(P-beta-CD), carboxymethyl-poly-beta-CD (CD-P-beta-CD), were used as chiral selector for separation of three basic drugs, lobeline, thiopendonesodium, flunarizine by capillary zone electrophoresis (CZE). All the five cyclodextrins have chiral separation ability to lobeline. P-beta-CD and CM-P-beta-CD have chiral recognition to thiopentonesodium and flunarizine. The results indicate that via optimizing separation conditions by varying pH and the concentration of chiral selectors the three racemic drugs could be baseline separated with 2% P-beta-CD or 0.5% CM-P-beta-CD in the buffer of 30 mmol/L Tris-H3PO4. And the best resolution ranging from 4 to 35 with CM-P-beta-CD as chiral additive was obtained within 10 min. The results were much better than those reported in other references.
%K capillary zone electrophoresis
%K cyclodextrin
%K thiopentonesodium
%K flunarizine
%K lobeline<br>硫喷妥钠
%K 盐酸氟桂利嗪
%K 山梗菜碱
%K CE
%K 手性拆分
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=6E709DC38FA1D09A4B578DD0906875B5B44D4D294832BB8E&cid=6579068328FE643F&jid=4D81E042D77AFEC6881D14759692069C&aid=9BA2AC08419A7FD8FF47E49A170D0F50&yid=9806D0D4EAA9BED3&vid=13553B2D12F347E8&iid=E158A972A605785F&sid=FA88DCCE84EA0A56&eid=5DCBAAB000A70168&journal_id=1000-8713&journal_name=色谱&referenced_num=0&reference_num=11