%0 Journal Article
%T Separation of Paroxetine and Its Intermediate Enantiomers by High Performance Liquid Chromatography Using Carboxy methyl-β-Cyclodextrin as Chiral Mobile Phase Additive<br>羧甲基-β-环糊精手性流动相添加剂法拆分帕罗西汀及其中间体对映体
%A LU Tiegang
%A YANG Maojun
%A <br>卢铁刚
%A 杨茂俊
%J 色谱
%D 2007
%I 
%X A high performance liquid chromatographic method to separate the respective enantiomers of paroxetine and its intermediate was developed using chiral mobile phase additive. Separation was performed on a Diamond C18 column (4.6 mm x 250 mm, 5 microm). The mobile phase was 0.1% phosphate acid-methanol (65 : 35, v/v) containing 0.38 g/L carboxymethyl-beta-cyclodextrin and the pH was adjusted to 7.2 by triethylamine. The detection wavelength was set at 210 nm and the temperature was 25 degrees C. With this method, paroxetine's trans/cis isomers and their enantiomers as well as intermediate HFP's trans/cis isomers and their enantiomers were separated simultaneously. The method is simple, rapid with high resolutions.
%K 高效液相色谱
%K 手性流动相添加剂
%K 羧甲基-β-环糊精
%K 对映体分离
%K 帕罗西汀
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=6E709DC38FA1D09A4B578DD0906875B5B44D4D294832BB8E&cid=6579068328FE643F&jid=4D81E042D77AFEC6881D14759692069C&aid=63F8F4FBFD00689499639E757FB05DF9&yid=A732AF04DDA03BB3&vid=C5154311167311FE&iid=B31275AF3241DB2D&sid=CE16DE2ABCD4D365&eid=07034C6B9EA4A53C&journal_id=1000-8713&journal_name=色谱&referenced_num=0&reference_num=12