%0 Journal Article
%T Research on the Separation Behavior of Acidic Drugs in Capillary Electrophoresis with Reversed Direction of Electroosmotic Flow<br>酸性药物的反向电渗流高效毛细管电泳分离分析研究
%A Lin Mei
%A Feng Min
%A Zhang Zhengxing
%A An Dengkui
%A Fan Guorong
%A <br>林梅
%A 冯敏
%A 张正行
%A 安登魁
%A 范国荣
%J 色谱
%D 1998
%I 
%X The separation behavior of acidic drugs in capillary electrophoresis with reversal of electroosmotic flow was investigated systematically. Acetylsalicylic acid and its related compound salicylic acid were employed as objective drugs. The cationic surfactant cetyltrimethylammonium bromide (CTAB) was used as reversed reagent for electroosmotic flow. The experimental conditions, such as, cationic surfactant concentration, buffer pH and organic additives, which affected migration time, peak shape and column efficiency, were studied in detail. The experimental results indicated that high speed analysis could be achieved in the capillary electrophoresis with reversed electroosmotic flow induced by cationic surfactant when acidic drugs were analysed. The poor peak shape and low column efficiency caused by the interactions of CTAB with acidic anions would be improved by adding proper organic additive, such as, beta-cyclodextrin or acetonitrile.
%K high performance capillary electrophoresis
%K reversed direction of electroosmotic flow
%K acidic drugs
%K salicylic acid
%K acetylsalicylic acid<br>HPCE
%K 酸性药物
%K 水杨酸
%K 乙酰水杨酸
%K 分离
%K 分析
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=6E709DC38FA1D09A4B578DD0906875B5B44D4D294832BB8E&cid=6579068328FE643F&jid=4D81E042D77AFEC6881D14759692069C&aid=F65B1163FA62F63D0C2AD3ACD2D2C129&yid=8CAA3A429E3EA654&vid=7801E6FC5AE9020C&iid=94C357A881DFC066&sid=663FF78B2ADE7A2D&eid=44FDB9366EDDFA2B&journal_id=1000-8713&journal_name=色谱&referenced_num=6&reference_num=1