%0 Journal Article
%T Preparation and Evaluation of Molecularly Imprinted Stationary Phase Used for Thin-Layer Chromatography<br>分子印迹薄层色谱手性固定相的制备及其色谱性能
%A RONG Fei
%A LI Ping
%A FENG Xiaogang
%A YUAN Chunwei
%A FU Degang
%A <br>戎非
%A 李萍
%A 冯小刚
%A 袁春伟
%A 付德刚
%J 色谱
%D 2006
%I 
%X Thin-layer chromatography (TLC) using molecularly imprinted polymers (MIPs) as chiral stationary phases (CSPs) was applied to the determination of enantiomers of mandelic acid and its derivatives. In preparation of MIPs, L-mandelic acid, L-2-chloromandelic acid and L-4-chloromandelic acid were employed as templates; acrylamide (AM) and ethylene glycol dimethacrylate (EGDMA) were used as functional monomer and cross-linker respectively. With the development system of acetonitrile-5% acetic acid, the racemates of templates were completely separated on the CSPs, the chiral separation factor a were 1.45, 1.62 and 1.56, respectively. Furthermore, the CSPs were able to resolve the racemates of template's derivatives. The relationship between the chemical structure of the analytes and chiral recognition of the CSPs was also investigated. This method provides a rapid, sensitive and convenient way of analyzing and determining the enantiomers of chiral compounds.
%K thin-layer chromatography(TLC)
%K molecularly imprinted polymers
%K chiral stationary phases
%K mandelic acid<br>薄层色谱
%K 分子印迹聚合物
%K 手性固定相
%K 扁桃酸
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=6E709DC38FA1D09A4B578DD0906875B5B44D4D294832BB8E&cid=6579068328FE643F&jid=4D81E042D77AFEC6881D14759692069C&aid=AA00BC3034DD36CA&yid=37904DC365DD7266&vid=B91E8C6D6FE990DB&iid=38B194292C032A66&sid=407C905D8F0449C4&eid=51C74DF6A16DA45B&journal_id=1000-8713&journal_name=色谱&referenced_num=3&reference_num=10