%0 Journal Article
%T Determination of Three Nitroimidazole Residues in Royal Jelly by High Performance Liquid Chromatography-Tandem Mass Spectrometry<br>高效液相色谱-串联质谱联用测定蜂王浆中的三种硝基咪唑类残留
%A DING Tao
%A XU Jinzhong
%A SHEN Chongyu
%A JIANG Yuan
%A CHEN Huilan
%A WU Bin
%A ZHAO Zengyun
%A LI Gonghai
%A ZHANG Jing
%A LIU Fei
%A <br>丁涛
%A 徐锦忠
%A 沈崇钰
%A 蒋原
%A 陈惠兰
%A 吴斌
%A 赵增运
%A 李公海
%A 张婧
%A 刘飞
%J 色谱
%D 2006
%I 
%X A method for analysis of trace metronidazole (MTZ), dimetridazole (DMZ) and ronidazole (RNZ) residues in royal jelly was developed by high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). After samples were dissolved in sodium hydroxide solution to disassociate target analytes from matrix, liquid-liquid extraction methods by ethyl acetate solvent were used. Matrix effects were minimized and good quantitation results were obtained by using highly-selective reaction monitoring (H-SRM) technology when deuterated dimetridazole (dimetridazole-D3) was selected as internal standard. Limits of detection (LODs) were 1.0 microg/kg for DMZ, 0.5 microg/kg for MTZ and RNZ (S/N > 5). Limits of quantitation (LOQs) were 2.0 microg/kg for DMZ, 1.0 microg/kg for MTZ and RNZ (S/N > 10). The linear ranges were 2.0 - 200 microg/L for all target analytes. Recoveries and relative standard deviations (RSDs) were in the ranges of 96.6% - 110.6% and 2.1% -7.4%, respectively. This method is suitable for statutory residue testing in the National Residue Surveillance Plan in China and meets the requirement for export.
%K high performance liquid chromatography(HPLC)
%K tandem mass spectrometry(MS/MS)
%K deuterated internal standard
%K nitroimidazole
%K royal jelly<br>高效液相色谱
%K 串联质谱
%K 同位素内标
%K 硝基咪唑类化合物
%K 蜂王浆
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=6E709DC38FA1D09A4B578DD0906875B5B44D4D294832BB8E&cid=6579068328FE643F&jid=4D81E042D77AFEC6881D14759692069C&aid=767A8CA987E89C4C&yid=37904DC365DD7266&vid=B91E8C6D6FE990DB&iid=E158A972A605785F&sid=717CC18E05F2AFA0&eid=9DC563A0FEFC04F9&journal_id=1000-8713&journal_name=色谱&referenced_num=8&reference_num=10