%0 Journal Article
%T Enantiomeric Separations of 1-1,2,4-Triazole Compounds by Micro-High Performance Liquid Chromatography<br>微径高效液相色谱法分离三唑类手性化合物的对映体
%A JIANG Zheng jin
%A GAO Ru yu
%A ZHANG Kai
%A ZHANG Zhi chao
%A WANG Qin sun
%A YAN Chao
%A <br>江正瑾
%A 高如瑜
%A 张锴
%A 张智超
%A 王琴孙
%A 阎超
%J 色谱
%D 2001
%I 
%X The enantiomeric separations of sixteen novel 1-1,2,4-triazole chiral compounds were investigated by micro-HPLC with a 200 mm x 100 microns i.d. capillary chiral OD column. The detection was performed at 223 nm. The mobile phase was a mixture of iso-propyl alcohol and n-hexane(20:80, V/V) at a flow rate of 30 microL/min and column head pressure of 6.9 MPa. Some of the enantiomers could be separated on baseline. In comparing with the separation results by the conventional HPLC method, the micro-HPLC method had the advantages of high-speed, economy, environmental friendliness etc. The effect of solute structure on enantio-selectivity was investigated and the chiral recognition mechanism was also discussed. It was found that the main separation mechanisms involve the pi-pi association and inclusion between the substituent R and the spiral pocket of OD-CSP.
%K micro
%K high performance liquid chromatography
%K high performance liquid chromatography
%K enantiomer separation
%K 1
%K 1
%K 2
%K 4
%K triazole chiral compound<br>微径高效液相色谱
%K 对映体分离
%K 三唑类手性农药
%K 杀菌剂
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=6E709DC38FA1D09A4B578DD0906875B5B44D4D294832BB8E&cid=6579068328FE643F&jid=4D81E042D77AFEC6881D14759692069C&aid=A9299F2A7139CFFF&yid=14E7EF987E4155E6&vid=2A8D03AD8076A2E3&iid=38B194292C032A66&sid=82722E2B785EBF0D&eid=627456E7977439A4&journal_id=1000-8713&journal_name=色谱&referenced_num=0&reference_num=6