%0 Journal Article
%T Effect of menthol cigarette on rats for metabonomics by liquid chromatography-mass spectrometry<br>基于液相色谱-质谱联用技术的代谢组学方法研究薄荷烟对大鼠代谢的影响
%A SHI Xianzhe
%A HE Zhihui
%A DOU Abo
%A ZHANG Fengxia
%A LIAN Wenliu
%A XU Guowang
%A <br>石先哲
%A 何智慧
%A 窦阿波
%A 张凤霞
%A 练文柳
%A 许国旺
%J 色谱
%D 2010
%I 
%X A liquid chromatography-mass spectrometry (LC-MS) method was developed for the metabonomics study of menthol cigarette effect on rats. Urines from three groups of rats were analyzed, including control rats, rats treated with menthol cigarette and rats treated with normal cigarette, and the data were processed by the method of principal component analysis (PCA). The PCA score plot showed that the metabolic difference between the rats treated with menthol cigarette and the control rats was smaller than that between the rats treated with normal cigarette and the control rats. Based on the PCA score plot, eight important metabolites, for example, kynurenic acid, were found and identified. Their relative concentration changes among the three groups further indicated that menthol cigarette maybe decrease the metabolic effect on rats.
%K liquid chromatography-mass spectrometry (LC-MS)
%K metabonomics
%K menthol cigarette
%K rats<br>液相色谱-质谱联用
%K 代谢组学
%K 薄荷烟
%K 大鼠
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=6E709DC38FA1D09A4B578DD0906875B5B44D4D294832BB8E&cid=6579068328FE643F&jid=4D81E042D77AFEC6881D14759692069C&aid=DCC612A671459F96937697C827447C3F&yid=140ECF96957D60B2&vid=D3E34374A0D77D7F&iid=5D311CA918CA9A03&sid=849F08713EB6820A&eid=B5D9C773C430C13C&journal_id=1000-8713&journal_name=色谱&referenced_num=0&reference_num=15