%0 Journal Article
%T Analysis of 1-(2,6-Dichlorophenyl)-2-Indolone and Related Materials by High Performance Liquid Chromatography<br>1-(2,6-二氯苯基)-2-吲哚酮及相关物质的HPLC分离分析
%A JI Qiong-mei
%A ZHANG Shu-sheng
%A HAO Qing-xiu
%A LIU Yu-hua
%A WU Yang-jie
%A <br>吉琼梅
%A 张书胜
%A 郝庆秀
%A 刘玉华
%A 吴养洁
%J 色谱
%D 2000
%I 
%X The separation of 1-(2,6-dichlorophenyl)-2-indolone (DCI) and related materials in the synthesis of medical intermediate DCI from 2, 6-dichlorophenol and phenylamine was investigated with high performance liquid chromatography under different chromatographic conditions. The results showed that DCI and related materials were in baseline separation by using CLC-CN(150 mm x 6.0 mm i.d., 7 microns) as column, MeOH-H2O(6:4, V/V) as mobile phase and a flow-rate at 1 mL/min. A rapid, accurate and reproducible HPLC method for determining DCI was developed. Fine and crude DCI samples were detected, results showed that N-(2,6-dichlorodiphenyl)-chloracetyl amide (CBCC) was the main impurity in fine sample, and CBCC and 2,6-dichlorodiphenylamine were the main impurities in the crude one.
%K high performance liquid chromatography
%K 1
%K (2
%K 6
%K dichlorophenyl)
%K 2
%K indolone and related compounds
%K impurity<br>高效液相色谱法
%K 吲哚酮
%K DCI
%K 分离分析
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=6E709DC38FA1D09A4B578DD0906875B5B44D4D294832BB8E&cid=6579068328FE643F&jid=4D81E042D77AFEC6881D14759692069C&aid=9C22766C03952430&yid=9806D0D4EAA9BED3&vid=13553B2D12F347E8&iid=CA4FD0336C81A37A&sid=E514EE58E0E50ECF&eid=014B591DF029732F&journal_id=1000-8713&journal_name=色谱&referenced_num=0&reference_num=4