%0 Journal Article
%T Direct Enantioseparation of Pantoprazole Sodium by High Performance Liquid Chromatography on Teicoplanin-Bonded Chiral Stationary Phase<br>替考拉宁键合手性固定相高效液相色谱法直接拆分泮托拉唑钠对映体
%A DING Guosheng
%A TANG Anna
%A WANG Junde
%A CONG Runzi
%A BAO Jianmin
%A <br>丁国生
%A 唐安娜
%A 王俊德
%A 丛润滋
%A 包建民
%J 色谱
%D 2006
%I 
%X Teicoplanin-bonded chiral stationary phase was prepared and used for the direct chiral separation of racemic pantoprazole sodium by reversed-phase high performance liquid chromatography (HPLC). The influences of organic modifiers, the composition of mobile phase, the flow rate and column temperature on enantioseparation were studied. It was found that methanol was preferred than acetonitrile when used as organic modifier. With the increase of column temperature, chiral solutes were less retained and the separation factor value decreased indicating that lower temperature was better for the enantioseparation. Better resolution was obtained at lower flow rates as a result of minimization of the resistance of mass transfer. Based on these experimental data, the chiral HPLC method for the analysis of pantoprazole sodium on prepared chiral column (150 mm x 4.6 mm i. d., 5 microm) was established with simplicity and good reproducibility, by using methanol-water (35 : 65, v/v) as mobile phase at a flow rate of 0.6 mL/min and 20 degrees C.
%K reversed-phase high performance liquid chromatography(RP-HPLC)
%K chiralstationary phase
%K enantioseparation
%K teicoplanin
%K pantoprazole sodium<br>反相高效液相色谱法
%K 手性固定相
%K 手性分离
%K 替考拉宁
%K 泮托拉唑钠
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=6E709DC38FA1D09A4B578DD0906875B5B44D4D294832BB8E&cid=6579068328FE643F&jid=4D81E042D77AFEC6881D14759692069C&aid=67E55E95E1A8EDBF&yid=37904DC365DD7266&vid=B91E8C6D6FE990DB&iid=CA4FD0336C81A37A&sid=D997634CFE9B6321&eid=B6DA1AC076E37400&journal_id=1000-8713&journal_name=色谱&referenced_num=0&reference_num=11