%0 Journal Article
%T Simultaneous Determination of Pseudoephedrine Hydrochloride and Dextromethorphan Hydrobromide in Composite Pseudoephedrine Hydrochloride Dry Suspension by HPLC<br>高效液相色谱法同时测定双酚伪麻干混悬剂中的盐酸伪麻黄碱和氢溴酸右美沙芬
%A LI Ke
%A <br>李克
%J 色谱
%D 2005
%I 
%X A simple and reliable reversed-phase high performance liquid chromatographic method (HPLC) for the routine analysis of pseudoephedrine hydrochloride and dextromethorphan hydrobromide in composite pseudoephedrine hydrochloride dry suspension has been established. HPLC determination for the drug was performed in a Lichrospher C6H6 column and detected at 220 nm. Acetonitrile-H2O-H3PO4 (50:50:0.1, v/v, pH 2.5, containing 1 g/L sodium dodecyl sulfate) was used as the mobile phase and the flow rate was 1.2 mL/min. The method was proved to be linear in the ranges of 1.03-206 mg/L and 5-200 mg/L for dextromethorphan hydrobromide and pseudoephedrine hydrochloride, respectively. The relative standard deviations of intra-assay (n = 7) and inter-assay (n = 5) were 1.0% and 1.5% for pseudoephedrine hydrochloride analysis and 1.8% and 2.2% for dextromethorphan hydrobromide analysis. The recoveries of pseudoephedrine hydrochloride and dextromethorphan hydrobromide were 95.7%-98.7% and 100.0%-101.8%, respectively. The method has been successfully applied to the simultaneous determination of pseudoephedrine hydrochloride and dextromethorphan hydrobromide in composite pseudoephedrine hydrochloride dry suspension.
%K reversed-phase high performance liquid chromatography
%K pseudoephedrine hydrochloride
%K dextromethorphan hydrobromide
%K composite pseudoephedrine hydrochloride dry suspension
%K drug<br>反相高效液相色谱
%K 盐酸伪麻黄碱
%K 氢溴酸右美沙芬
%K 双酚伪麻干混悬剂
%K 药物
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=6E709DC38FA1D09A4B578DD0906875B5B44D4D294832BB8E&cid=6579068328FE643F&jid=4D81E042D77AFEC6881D14759692069C&aid=CBAD075EE54961E8&yid=2DD7160C83D0ACED&vid=EA389574707BDED3&iid=CA4FD0336C81A37A&sid=0D0D661F0B316AD5&eid=656F8C8401D91023&journal_id=1000-8713&journal_name=色谱&referenced_num=0&reference_num=6