%0 Journal Article
%T Determination of dichloromethane and trichloromethane residues in ranitidine hydrochloride by headspace liquid phase microextraction coupled with gas chromatography<br>顶空液相微萃取-气相色谱法测定盐酸雷尼替丁中二氯甲烷和三氯甲烷的残留量
%A SHEN Shuchang
%A YUN Dan
%A LI Fei
%A <br>申书昌
%A 云丹
%A 李飞
%J 色谱
%D 2009
%I 
%X A method for the determination of residual dichloromethane and trichloromethane in ranitidine hydrochloride by headspace liquid phase microextraction coupled with gas chroma-tography (GC) was developed. A homemade device was used to protect the organic drop. The effects of the nature of extraction solvent, extraction time, extraction temperature and micro-drop volume on the extraction efficiency were investigated separately. The optimal experimen-tal conditions were as follows:2 ΜL of n-tridecane as extraction solvent, 30 min of extraction time, 60 ℃ of extraction temperature. The correlation coefficients of linear calibration curve were 0. 973 3 and 0. 972 4 within the concentration ranges of dichloromethane (1-10 μg/g) and trichloromethane (1-10 μg/g), respectively. The detection limits of dichlormethane and tri-chloromethane were 0. 027 3 μg/g and 0. 041 0 μg/g, respectively, the relative standard devia-tions were lower than 4. 36% and 5. 89%, and the recoveries of the method were 93. 6% - 102% and 98.1% -103%, respectively. The method is simple and reliable.
%K liquid phase microextraction
%K gas chromatography ( GC)
%K dichloromethane
%K trichloromethane
%K ranitidine hydrochloride<br>液相微萃取
%K 气相色谱法
%K 二氯甲烷
%K 三氯甲烷
%K 盐酸雷尼替丁
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=6E709DC38FA1D09A4B578DD0906875B5B44D4D294832BB8E&cid=6579068328FE643F&jid=4D81E042D77AFEC6881D14759692069C&aid=475AEFF846CC699E4BE5A4509694B071&yid=DE12191FBD62783C&vid=DB817633AA4F79B9&iid=B31275AF3241DB2D&sid=450524CAAD043961&eid=51E4ADE955550A0C&journal_id=1000-8713&journal_name=色谱&referenced_num=0&reference_num=14