%0 Journal Article
%T Study on the Analysis of Zinc 5 Aminosalicylate and Related Compounds by High Performance Liquid Chromatography<br>5-氨基水杨酸锌及相关物质的高效液相色谱分析研究
%A Liu Hongxia
%A Zhang Shusheng
%A <br>刘红霞
%A 张书胜
%A 袁倬斌
%J 色谱
%D 1998
%I 
%X In this paper, the separation and determination conditions of zinc 5-aminosalicylate (ZASA) and related compounds by high performance liquid chromatography(HPLC) have been studied systematically. The baseline separation was achieved at 20 degrees C on a CLC-ODS column(150 mm x 6.0 mm i.d., 10 microns) within 10 minutes by using 1% (V/V) HAc-MeOH(4:6) as mobile phase at a flow-rate of 1 mL/min. The RSDs of rention time within day and between days were less than 2% and 5% respectively. The injection volume was 20 microL, and relationships between the peak area with 280 nm detection and the analyte concentration were linear within certain ranges. This method was used for determination of ZASA, impurities and thermal decomposition compounds. The results showed that the impurities in the crude ZASA were 5-aminosalicylic acid and salicylic acid. The thermal decomposition compounds in acid medium were 5-aminosalicylic acid, 5-aminophenol and 5-benzeneazosalicylic acid.
%K high performance liquid chromatography
%K zinc 5 aminosalicylate
%K 5 aminosalicylic acid
%K salicylic acid
%K p
%K aminophenol
%K 5 benzeneazosalicylic acid<br>氨基水杨酸锌
%K 合成
%K 对氨基苯酚
%K HPLC
%K 分析
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=6E709DC38FA1D09A4B578DD0906875B5B44D4D294832BB8E&cid=6579068328FE643F&jid=4D81E042D77AFEC6881D14759692069C&aid=F65B1163FA62F63DD15EEECEE4EAE46D&yid=8CAA3A429E3EA654&vid=7801E6FC5AE9020C&iid=E158A972A605785F&sid=4AD4BA66429F5627&eid=892C6E385D640C1E&journal_id=1000-8713&journal_name=色谱&referenced_num=3&reference_num=0