%0 Journal Article
%T Determination of Valproic Acid Level in Serum by High Performance Liquid Chromatography<br>高效液相色谱法快速测定人血清中丙戊酸含量
%A Xiao Hong
%A Zhang Shining
%A <br>肖红
%A 张石宁
%J 色谱
%D 1998
%I 
%X A method for the determination of valproic acid level in serum with high performance liquid chromatography was established. The conditions were Zorbax ODS (250 mm x 4.6 mm, 5 microns) column, 0.8 mL/min sulfuric acid solution (pH 4.2) eluent and UV-210 nm detector. The linear range was 0.82 mumol/L to 1.8 mumol/L (r = 0.996) and the detection limit was 0.82 mumol/L. The average recovery was 98.32% +/- 2.27% and the coefficients of variation were 3.31% (n = 5) and 4.82% (n = 7) for within-day and day-to-day tests respectively. This direct method was compared with the derivatization method.
%K high performance liquid chromatography
%K valproic acid
%K serum concentration<br>高效液相色谱法，丙戊酸，血浓度
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=6E709DC38FA1D09A4B578DD0906875B5B44D4D294832BB8E&cid=6579068328FE643F&jid=4D81E042D77AFEC6881D14759692069C&aid=F65B1163FA62F63DF6D2D773B990D014&yid=8CAA3A429E3EA654&vid=7801E6FC5AE9020C&iid=E158A972A605785F&sid=683005D16807E4FE&eid=2E41258BCB9A7DB2&journal_id=1000-8713&journal_name=色谱&referenced_num=1&reference_num=1