%0 Journal Article
%T Enantiomeric Resolution by Chiral Ligand-Exchange Chromatography with Chiral Mobile Phase<br>手性配位体交换流动相添加剂法拆分对映体
%A Li Xin
%A Zeng Su
%A <br>李新
%A 曾苏
%J 色谱
%D 1996
%I 
%X Chiral ligand-exchange chromatography(CLEC),in which three types of chiral LC systems are generally employed,is revieved with emphasis on the chiral mobile phase. The main points include : (A) Mechanism of chiral ligand-exchange chromatography. Equations are given describing the retention and separation selectivity of two enantiomeric species in a chromatographic system containing a chiral selector in the stationary and/or in the mobile phase. It is shown that the total column enantioselectivity generally differs from the enantioselectivity of the selector-selectand interaction in solution. (B)Parameters affecting ligand exchange. Twelve factors are disscused including metal ions, metal/ligand ratio, concentration of metal/complex, stationary phase, eluent PH, elution order,organic medifier, ion-pair reagent, ion strength of mobile phase, temperature,stereoselectivity, and mutual recognition. (C) Applications. Some enantiomers separated by CMPs of CLEC are presented as examples.
%K chiral ligand-exchange chromatography
%K mobile additive
%K separation of enantiomers<br>手性配合基
%K 交换色谱法
%K 流动相添加剂
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=6E709DC38FA1D09A4B578DD0906875B5B44D4D294832BB8E&cid=6579068328FE643F&jid=4D81E042D77AFEC6881D14759692069C&aid=798AA8339DF84A0E93C70308CE28902D&yid=8A15F8B0AA0E5323&vid=F3583C8E78166B9E&iid=94C357A881DFC066&sid=0954045FA0C6885F&eid=3356A7630A93A219&journal_id=1000-8713&journal_name=色谱&referenced_num=7&reference_num=5