%0 Journal Article
%T An Improvement on Determination of the Related Substances in Vindesine Sulfate and Its Injection<br>硫酸长春地辛及其注射剂有关物质检查方法的改进
%A Chen Jue
%A Huang Zongyu
%A <br>陈珏
%A 黄宗玉
%J 色谱
%D 1999
%I 
%X A new method for the analysis of related substances in vindesine sulfate and its injection to improve the ability of separation by RP-HPLC was established. The separation was achieved by applying a reversed-phase C18 column (150 mm x 4.6 mm i.d.) and a mixture of V(MeOH):V(buffer solution) = 70:30 as mobile phase. The buffer solution was an aqueous solution of volume fraction 1.5% diethylamine adjusted to pH 7.5 with phosphoric acid. The UV-detector was set at 267 nm. Four related substances were separated from vindesine within thirteen minutes. The tailing factor of the peak of vindesine is 1.00-1.05. The results showed that this method is more efficient for separating the related substances in vindesine sulfate than the conventional method.
%K reversed phase high performance liquid chromatography
%K vindesine sulfate
%K injection
%K related substance<br>高效液相色谱法，硫酸长春地辛，注射剂，杂质
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=6E709DC38FA1D09A4B578DD0906875B5B44D4D294832BB8E&cid=6579068328FE643F&jid=4D81E042D77AFEC6881D14759692069C&aid=D7F5F79B7B81B86202ABEEE633CAF1A1&yid=B914830F5B1D1078&vid=BCA2697F357F2001&iid=CA4FD0336C81A37A&sid=CD775AE9DDBD7B53&eid=7AA74D31F1FF2DCE&journal_id=1000-8713&journal_name=色谱&referenced_num=0&reference_num=1