%0 Journal Article
%T Reversed-Phase High Performance Liquid Chromatographic(RP-HPLC ) Determination and the Study of Pharmacokinetic Parameters of Caffeine in Saliva and Serum<br>反相高效液相色谱法测定唾液和血清咖啡因浓度及药代动力学参数的研究
%A 李群安
%A 张开宿
%J 色谱
%D 1994
%I 
%X 用反相高效液相色谱法测定４０只Ｗｉｓｔａｒ雄性大鼠和２４例健康人静注咖啡因１ｍｇ／ｋｇ或口服４ｍｇ／ｋｍ后血清及唾液ＣＡＦ浓度，并根据血药或唾药－时间数据计算其药学参数，大鼠的血药－时间数据符合二室开放模型，各肝损害组与正常组（每组１０只）的ｔ１／２βＶｃ，Ｋ２１差异显著（均Ｐ＜０．０１）。提示血清ＣＡＦ药动学参数可定量检测肝代谢功能。２４例健康人唾液与血清ＣＡＦ浓度及ｔ１／２均良好相关性（γ＝０
%K reversed-phase high performance liquid chromatagraphy
%K caffeine
%K serum
%K saliva
%K liver metabolic function
%K pharmaeokinetics<br>液相色谱
%K 咖啡因
%K 血清
%K 药代动力学
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=6E709DC38FA1D09A4B578DD0906875B5B44D4D294832BB8E&cid=6579068328FE643F&jid=4D81E042D77AFEC6881D14759692069C&aid=69FF2EFAFF99B412C4C56C85BAE38678&yid=3EBE383EEA0A6494&vid=59906B3B2830C2C5&iid=E158A972A605785F&sid=9F8C5EF901EA1E7E&eid=7979125BBE749348&journal_id=1000-8713&journal_name=色谱&referenced_num=4&reference_num=1