%0 Journal Article
%T Simultaneous Determination of Chlorpheniramine, Paracetamol and Pseudo-ephedrine Hydrochloride in Composite Tablets by High Performance Liquid Chromatography<br>高效液相色谱法同时测定诺诺感冒片中扑尔敏、扑热息痛、盐酸伪麻黄碱的含量
%A CHEN Zhu ling
%A ZHANG Lan
%A WANG Min
%A HUANG Ying
%A <br>陈珠灵
%A 张兰
%A 王敏
%A 黄颖
%J 色谱
%D 2001
%I 
%X An HPLC method is described for the determination of chlorpheniramine, paracetamol and pseudoephedrine hydrochloride simultaneously in Nuonuo composite tablets. Chromatographic conditions were: column, YWG-C18 column (150 mm x 4.0 mm i.d., 10 microns); mobile phase, 25% methanol(0.05 mol/L sodium dihydrogen phosphate); flow rate, 1.0 mL/min; detection wavelength, 205 nm; injection volume, 20 microL. The detection limits of chlorpheniramine, paracetamol and pseudo-ephedrine hydrochloride were 1.16 mg/L, 0.15 mg/L and 1.82 mg/L respectively and the corresponding average recoveries were 98.35% (n = 5, RSD = 1.60%), 101.16% (n = 5, RSD = 1.50%) and 98.50% (n = 5, RSD = 1.59%) respectively. The proposed method is simple, rapid and accurate and has been satisfactorily used for the quantitative analysis of real samples.
%K high performance liquid chromatography
%K chlorpheniramine
%K paracetamol
%K pseudo
%K ephedrine hydrochloride
%K Nuonuo composite tablets<br>高效液相色谱法
%K 扑尔敏
%K 扑热息痛
%K 盐酸伪麻黄碱
%K 诺诺感冒片
%K 药物分析
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=6E709DC38FA1D09A4B578DD0906875B5B44D4D294832BB8E&cid=6579068328FE643F&jid=4D81E042D77AFEC6881D14759692069C&aid=18E0BBD04243AE45&yid=14E7EF987E4155E6&vid=2A8D03AD8076A2E3&iid=38B194292C032A66&sid=FBCA02DBD05BD4EA&eid=9CA95D22FC1D537C&journal_id=1000-8713&journal_name=色谱&referenced_num=8&reference_num=8