%0 Journal Article
%T Development of Desulfated Chondroitin Sulfate C as a Novel Chiral Selector in Capillary Electrophoresis and Enantioseparation of Cilnidipine<br>毛细管电泳手性选择剂去硫酸基硫酸软骨素C的研究开发及新药西尼地平对映体的拆分
%A DU Yingxiang
%A DI Bin
%A CHEN Jianmin
%A ZHENG Zhaohua
%A <br>杜迎翔
%A 狄斌
%A 陈建民
%A 郑朝华
%J 色谱
%D 2004
%I 
%X Desulfated chondroitin sulfate C, a synthetic polysaccharide, was successfully developed as a novel chiral selector in capillary electrophoresis. It was first applied to the enantioseparation of the drugs of dihydropyridine class. The racemic mixture of cilnidipine, a new calcium channel antagonist for the treatment of hypertension, was resolved for the first time. The effects of buffer pH, concentration of the chiral additive and applied voltage on the chiral separation were investigated. The optimum conditions were pH 2.50, 30 (g/L) for additive concentration and 10 kV for applied voltage. Under the optimized conditions the enantiomers of cilnidipine were completely separated with a resolution factor of 2.01. The method is simple and rapid with high separation efficiency.
%K capillary electrophoresis
%K chiral selector
%K chiral separation
%K polysaccharides
%K de-(sulfated) chondroitin sulfate C
%K cilnidipine<br>毛细管电泳
%K 手性选择剂
%K 手性分离
%K 多糖
%K 去硫酸基硫酸软骨素C
%K 西尼地平
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=6E709DC38FA1D09A4B578DD0906875B5B44D4D294832BB8E&cid=6579068328FE643F&jid=4D81E042D77AFEC6881D14759692069C&aid=3F73D36A4967BAB9&yid=D0E58B75BFD8E51C&vid=BC12EA701C895178&iid=E158A972A605785F&sid=9C82B18080268586&eid=44FDB9366EDDFA2B&journal_id=1000-8713&journal_name=色谱&referenced_num=2&reference_num=20