%0 Journal Article
%T A Fast Response Highly Selective Probe for the Detection of Glutathione in Human Blood Plasma
%A Yixing Guo
%A Xiaofeng Yang
%A Lovemore Hakuna
%A Aabha Barve
%A Jorge O. Escobedo
%A Mark Lowry
%A Robert M. Strongin
%J Sensors
%D 2012
%I MDPI AG
%R 10.3390/s120505940
%X A fluorescent probe for glutathione (GSH) detection was developed. Our study indicates a possible mechanism which couples a conjugate addition and micelle-catalyzed large membered ring formation/elimination sequence. This method enables excellent selectivity towards GSH over other biological thiols such as cysteine (Cys) and homocysteine (Hcy). The proposed method is precise with a relative standard deviation (R.S.D) lower than 6% (n = 3) and has been successfully applied to determine GSH in human plasma with recoveries between 99.2% and 102.3%.
%K fluorescent probe
%K glutathione
%K micelle-catalyzed
%K selectivity
%U http://www.mdpi.com/1424-8220/12/5/5940