%0 Journal Article
%T Molecular structure and biological function of proliferating cell nuclear antigen<br>
%A Song Nanmeng
%A Sang Jianli
%A Xu Heng
%A <br>
%J 自然科学进展
%D 2007
%I 
%X Proliferating cell nuclear antigen (PCNA) is the core component of replication complex in eukaryote. As a processive factor of DNA polymerase delta, PCNA coordinates the replication process by interacting with various replication proteins. PCNA appears to play an essential role in many cell events, such as DNA damage repair, cell cycle regulation, and apoptosis, through the coordination or organization of different partners. PCNA is an essential factor in cell proliferation, and has clinical significance in tumor research. In this article we review the functional structure of PCNA, which acts as a function switch in different cell events.
%K PCNA
%K Function Switch
%K PCNA Binding Motif
%K Cell Cycle
%K DNA Replication
%K DNA Repair<br>
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=01BA20E8BA813E1908F3698710BBFEFEE816345F465FEBA5&cid=96E6E851B5104576C2DD9FC1FBCB69EF&jid=504AF8C1E5476CA7C4EC9DF6FEAC14AC&aid=B8DC26B0FD2C4428AF6ADA34DFED5A4D&yid=A732AF04DDA03BB3&vid=BCA2697F357F2001&iid=F3090AE9B60B7ED1&sid=FB318F788ECEF1B2&eid=4A8E5D086592D016&journal_id=1002-008X&journal_name=自然科学进展&referenced_num=0&reference_num=0