%0 Journal Article
%T Development of Treatment Concepts for the Use of Botulinum Toxin A in Children with Cerebral Palsy
%A Richard Placzek
%A Dagmar Siebold
%A Julia F. Funk
%J Toxins
%D 2010
%I MDPI AG
%R 10.3390/toxins2092258
%X The treatment of children with cerebral palsy with Botulinum toxin A injections is well established, safe and effective. However, a standardized injection strategy is still missing and the used dosage has escalated over the years. In the recent past, the recommended dosages in Europe were, however, reduced due to a better understanding of the relationship between dosage, severe side effects and the kind of anesthesia used. To combine safety and efficacy, the trend tends to a lower dosage, but combined with a more specific selection of injected muscles. The treatment of these key-muscles takes into account the best support for motor development to attain each individual motor milestone.
%K botulinum toxin A
%K cerebral palsy
%K CP
%K multi-level treatment
%K key-muscle concept
%U http://www.mdpi.com/2072-6651/2/9/2258