%0 Journal Article
%T Mitochondrial DNA mutation in essential hypertension
%A Yuqi Liu
%A Shiwen Wang
%A <br>Yuqi Liu
%A Shiwen Wang
%J 老年心脏病学杂志(英文版)
%D 2008
%I Science Press
%X Essential hypertension (EH) is an escalating problem for developed and developing countries.It is currently seen as a 'complex' genetic trait caused by multiple susceptibility genes which are modulated by gene-environment and gene-gene interactions.Over the past 10 years,mitochondrial defects have been implicated in a wide variety of degenerative diseases,aging,and cancer.Recently several studies showed that human essential hypertension has excess maternal transmission which suggests a possible mitochondrial involvement.However,the exact pathophysiology of mitochondrial DNA mutation (mtDNA) in essential hypertension still remains perplexing.With the application of a variety of imaging approaches and successive mouse model of mitochonddal diseases we convince that these problems will be resolved in the near future.(J Geriatr Cardiol 2008;5(1):60-64)
%K mitochondrial DNA
%K essential hypertension
%K maternal
%K genetic trait
%K modulated<br>
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=A9DB1C13C87CE289EA38239A9433C9DC&cid=AD36F34DDC3BA7B0&jid=4DC702B3A2386A4814E2FF9CFB799B27&aid=A43B813737F33A3087D1FDD40DF4AC8D&yid=67289AFF6305E306&vid=94C357A881DFC066&iid=CA4FD0336C81A37A&sid=BFE7933E5EEA150D&eid=0401E2DB1F51F8DE&journal_id=1671-5411&journal_name=Journalofgeriatriccardiology:JGC&referenced_num=0&reference_num=58