%0 Journal Article
%T Characteristics of Polysilicon Wire Glucose Sensors with a Surface Modified by Silica Nanoparticles/¦Ã-APTES Nanocomposite
%A Jing-Jenn Lin
%A Po-Yen Hsu
%A You-Lin Wu
%A Jheng-Jia Jhuang
%J Sensors
%D 2011
%I MDPI AG
%R 10.3390/s110302796
%X This report investigates the sensing characteristics of polysilicon wire (PSW) glucose biosensors, including thickness characteristics and line-width effects on detection limits, linear range and interference immunity with membranes coated by micropipette/spin-coating and focus-ion-beam (FIB) processed capillary atomic-force-microscopy (C-AFM) tip scan/coating methods. The PSW surface was modified with a mixture of 3-aminopropyl-triethoxysilane (¦Ã-APTES) and polydimethylsiloxane (PDMS)-treated hydrophobic fumed silica nanoparticles (NPs). We found that the thickness of the ¦Ã-APTES+NPs nonocomposite could be controlled well at about 22 nm with small relative standard deviation (RSD) with repeated C-AFM tip scan/coatings. The detection limit increased and linear range decreased with the line width of the PSW through the tip-coating process. Interestingly, the interference immunity ability improves as the line width increases. For a 500 nm-wide PSW, the percentage changes of the channel current density changes (¦¤J) caused by acetaminophen (AP) can be kept below 3.5% at an ultra-high AP-to-glucose concentration ratio of 600:1. Simulation results showed that the line width dependence of interference immunity was strongly correlated with the channel electrical field of the PSW biosensor.
%K line width dependence
%K polysilicon wire
%K ¦Ã-APTES
%K PDMS
%K silica nanoparticles
%U http://www.mdpi.com/1424-8220/11/3/2796