%0 Journal Article
%T The role of hydrogen sulfide system in the pathogenesis of renovascular hypertension in rats<br>Hydrogen sulfide system in the pathogenesis of renovascular hypertension in rats
%A Youqin Cheng
%A Daiqin Wu
%A Guang Yang
%A Xiaoying Li
%A Dayan Huang
%A Bin Geng
%A Chaoshu Tang
%A <br>Youqin Cheng
%A Daiqin Wu
%A Guang Yang
%A Xiaoying Li
%A Dayan Huang
%A Bin Geng
%A Chaoshu Tang
%J 老年心脏病学杂志(英文版)
%D 2008
%I Science Press
%X Objective To investigate the role of hydrogen sulfide (H2S) synthases/H2S pathway in the pathogenesis of renovascular hypertension.Methods Wistar rats were subdivided into 4 groups:(1) 2-kidney,1-clip (2K-1C group,n=7),(2) control (n=7),(3)sham (n=7),and (4) 2K-1C plus sodium hydrosulfide (NariS) (NariS-treated group,n=7).The systolic blood pressure (SBP) was measured by a tail-cuff method using a pulse transducer once a week.Four weeks later,all rats were killed and the concentration of plasma hydrogen sulfide (H2S),the activity of the H2S syntha.ses in the kidneys on both sides,the plasma angiotensin Ⅱ concentration,and the left-to-whole heart weight ratio were measured.Results The SBP was significantly increased in the 2K-IC group (185.4± 14.0mmHg) comparing with those in the sham group (112.9±6.5mmHg,,or the NariS-treated group(134.8±9.5mmHg) (both P＜0.01).At 4 weeks,the angiotensin Ⅱ concentration in the plasma was increased in the 2K-1C and NariS-treated group,comparing with the control and the sham group (306.92±7.03 pg/ml and 240.73±13.22 pg/ml vs 122.6±25.49 pg/ml and 125.95±10.55 pg/ml,respectively,both P＜0.05).The plasma H2S concentration and the activity of H2S synthases in the left kidney were decreased in the 2K-1C group comparing with those in the sham and the control groups.There was no difference of the activity of the H2S synthases in the right kidneys among the 4 groups.The left-to-whole heart weight ratio was increased in the 2K-1C and the NariS-treated group camparing with that in the sham and natural control groups.Conclusions Dysfunction of the H2S synthases/H2S pathway was involved in the 2K-1C-induced renovascular hypertension in rat.Exogenous administration of H2S donor can attenuate the development of hypertension.These findings suggest that the H2S synthases/H2S pathway participates in the pathogenesis of renovascular hypertension.
%K angiotensin
%K hypertension
%K renal
%K blood pressure
%K hydrogen sulfide<br>
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=A9DB1C13C87CE289EA38239A9433C9DC&cid=AD36F34DDC3BA7B0&jid=4DC702B3A2386A4814E2FF9CFB799B27&aid=D800FEDD27B0FF1735F0AC323A048214&yid=67289AFF6305E306&vid=94C357A881DFC066&iid=0B39A22176CE99FB&sid=94E7F66E6C42FA23&eid=2A3781E88AB1776F&journal_id=1671-5411&journal_name=Journalofgeriatriccardiology:JGC&referenced_num=1&reference_num=13