%0 Journal Article
%T Effect of early correction of anemia with erythropoietin on left ventricular mass in predialysis patients: a multi-center trial<br>Effect of early correction of anemia with erythropoietin on left ventricular mass in predialysis patients:a multi-center trial
%A Fanfan HOU
%A Jianping JIANG
%A Lizhen GAO
%A Yangbin PAN
%A Niansheng YANG
%A Wei CHEN
%A Guiyang SHU
%A Youming CHEN
%A Jian CHEN
%A Weihua PENG
%A Jianping WU
%A Zhongmin YANG
%A <br>Fanfan HOU
%A Jianping JIANG
%A Lizhen GAO
%A Yangbin PAN
%A Niansheng YANG
%A Wei CHEN
%A Guiyang SHU
%A Youming CHEN
%A Jian CHEN
%A Weihua PENG
%A Jianping WU
%A Zhongmin YANG Division of Nephrology
%A Nanfang Hospital
%A Guanzhou
%A China
%J 老年心脏病学杂志(英文版)
%D 2005
%I Science Press
%X Objective To assess the effects of early correction of anemia with recombinant human erythropoietin (rHuEPO) on the develop-ment and progression of left ventricular hypertrophy (LVH) in patients with mild-to-moderate chronic renal insufficiency (CRI) who are not on hemodialysis. Methods A total of 158 patients with serum creatinine from 147jJ.mol/L to 40()p_mol/L were enrolled in this prospective, multicenter study. Eighty-six patients with hemoglobin (Hb) 1 lOg/L (Group A). Forty patients with comparable Hb concentration ( <1 lOg/L) but did not receive rHuEPO (Group B) and 32 patients with Hb>l lOg/L and without rHuEPO treatment (Group C) were served as controls. Left ventricular mass index (LVMI) was evaluated by echocardiography at baseline and every 3 months for 2 years. Results There was no difference in age, gender, etiology of renal failure, blood pressure and cardiovascular risk factors among the 3 groups. At baseline, the prevalence of LVH was 72.1% in group A, 72.5% in group B and 59.4% in group C. LVMI was inversely correlated with Hb levels (r=0.70, P<0.01). During the 2-year period, the mean LVMI decreased from 142.6±25.7g/m: to 132.4±18.5 g/nr in group A, while increased significantly in both group B and group C. The mean Hb concentration increased from 93.8±i4.6g/L to 111.2±10.3g/L (P<0.05) in group A, but tended to decrease in group B and group C. There was no significant change of the mean blood pressure, number of anti-hypertensive drugs and serum creatinine concentrations in all 3 groups. However, patients' serum creatinine doubled more often in group B and group C than in group A. Conclusions LVH was common in predialysis CRI patients and was associated with the severity of anemia. Early intervention with rHuEPO may reverse LVH in these patients.
%K renal failure
%K chronic
%K anemia
%K left ventricular hypertrophy
%K erythropoietin<br>
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=A9DB1C13C87CE289EA38239A9433C9DC&cid=AD36F34DDC3BA7B0&jid=4DC702B3A2386A4814E2FF9CFB799B27&aid=D0307B07A6B61C81FE113C49D5E82DBD&yid=2DD7160C83D0ACED&vid=0B39A22176CE99FB&iid=38B194292C032A66&sid=58F693790F887B3B&eid=12DC19455C3A2FA8&journal_id=1671-5411&journal_name=Journalofgeriatriccardiology:JGC&referenced_num=0&reference_num=18