%0 Journal Article
%T Neuregulin-1 therapy improved cardiac function and reduced ANPmRNA expression in post myocardial infarction rats with cardiac dysfunction
%A Yuanfang LI
%A Naisheng CAI
%A Xinghua GU
%A Jingmin ZHOU
%A Keqiang WANG
%A Yunzeng ZOU
%A Junbo GE
%A <br>Yuanfang LI
%A Naisheng CAI
%A Xinghua GU
%A Jingmin ZHOU
%A Keqiang WANG
%A Yunzeng ZOU
%A Junbo GE
%J 老年心脏病学杂志(英文版)
%D 2005
%I Science Press
%X Objective To observe the influence of neuregulin-1 on the cardiac function of post-myocardial infarction rats. Methods Left ventricular MI was created in Sprague-Dawley rats by ligalion of the left anterior descending coronary. Six months after the operation, rats were evaluated with echocardiology methods. 36 rats that had an infarct area and a EF around 60% were randomized into 3 groups: MI group(n=12) were injected a blank vehicle fluid intravenously for 5 days, after which they continued to be raised on standard food and water for 30 days. MI+NRG group(n=12). received NRG-1 10(J.g ? kg ' intravenously for 5 days, after which they continued to be raised on standard food and water for 30 days. Ml+Capl group (n=12) received captopril orally (dissolved in their drinking water 2g/L) for 30 days , after which tap water substituted the solution for 5 days. Final echocardiographic and hcmodynamic measurements were made at the end of 1 month of therapy. Total RNA was extracted from fro/en left ventricular tissues, and was reverse transcribed into first-strand PCR was performed with primers for BNPx ANP. Results Rats treated with neuregulin had a smaller LVDs (F=0.()14), a better LVEF (P=0.004 ),and a tendency towards less lung perfusion than untreated rats. Neuregulin decreased the expression of ANP mRNA in the ventricle (P=0.025 ).Conclusion Neuregulin markedly improved the cardiac function of rats that survived myocardial infarction, and decreased the expression of ANP mRNA in the ventricle.
%K neuregulin-1
%K myocardial infarction
%K heart failure
%K atrial natriuetic peptide<br>
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=A9DB1C13C87CE289EA38239A9433C9DC&cid=AD36F34DDC3BA7B0&jid=4DC702B3A2386A4814E2FF9CFB799B27&aid=4A17BD85F541662FA44A1905A9776CC8&yid=2DD7160C83D0ACED&vid=0B39A22176CE99FB&iid=E158A972A605785F&sid=FBCA02DBD05BD4EA&eid=1DF3F9D75A12D97B&journal_id=1671-5411&journal_name=Journalofgeriatriccardiology:JGC&referenced_num=0&reference_num=14