%0 Journal Article
%T Prevalence of and risk factors for aspirin resistance in elderly patients with coronary artery disease<br>Prevalence and Risk Factors for Aspirin Resistance in Elderly Patients with Coronary Artery Disease
%A Xian-Feng Liu
%A Jian Cao
%A Li Fan
%A Lin Liu
%A Jian Li
%A Guo-Liang Hu
%A Yi-Xin Hu
%A Xiao-Li Li
%A <br>Xian-Feng Liu
%A Jian Cao
%A Li Fan
%A Lin Liu
%A Jian Li
%A Guo-Liang Hu
%A Yi-Xin Hu
%A Xiao-Li Li
%J 老年心脏病学杂志(英文版)
%D 2013
%I Science Press
%X Objective To assess the prevalence of and related risk factors for aspirin resistance in elderly patients with coronary artery disease (CAD). Methods Two hundred and forty-six elderly patients (75.9 ± 7.4 years) with CAD who received daily aspirin therapy (≥ 75 mg) over one month were recruited. The effect of aspirin was assessed using light transmission aggregometry (LTA) and thrombelastography platelet mapping assay (TEG). Aspirin resistance was defined as ≥ 20% arachidonic acid (AA)-induced aggregation and ≥ 70% adenosine diphosphate (ADP)-induced aggregation in the LTA assay. An aspirin semi-responder was defined as meeting one (but not both) of the criteria described above. Based on the results of TEG, aspirin resistance was defined as ≥ 50% aggregation induced by AA. Results As determined by LTA, 23 (9.3%) of the elderly CAD patients were resistant to aspirin therapy; 91 (37.0%) were semi-responders. As determined by TEG, 61 patients (24.8%) were aspirin resistant. Of the 61 patients who were aspirin resistant by TEG, 19 were aspirin resistant according to LTA results. Twenty-four of 91 semi-responders by LTA were aspirin resistant by TEG. Multivariate logistic regression analysis revealed that elevated fasting serum glucose level (Odds ratio: 1.517; 95% CI: 1.176–1.957; P = 0.001) was a significant risk factor for aspirin resistance as determined by TEG. Conclusions A significant number of elderly patients with CAD are resistant to aspirin therapy. Fasting blood glucose level is closely associated with aspirin resistance in elderly CAD patients.
%K Aspirin resistance
%K Coronary artery disease
%K Risk factors<br>
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=A9DB1C13C87CE289EA38239A9433C9DC&cid=AD36F34DDC3BA7B0&jid=4DC702B3A2386A4814E2FF9CFB799B27&aid=5F1383ACA8CAEE92315F931D624C6E82&yid=FF7AA908D58E97FA&vid=F3090AE9B60B7ED1&iid=CA4FD0336C81A37A&sid=659D3B06EBF534A7&eid=DB817633AA4F79B9&journal_id=1671-5411&journal_name=Journalofgeriatriccardiology:JGC&referenced_num=0&reference_num=0