%0 Journal Article
%T Relationship between platelet P-selectin and severity of acute coronary syndromes<br>
%A Rui Wang
%A Jiyuan Lu
%A Yongping Jia
%A Yuping Gao
%A Chunyu Fan
%A Fang Li
%A <br>
%J 老年心脏病学杂志(英文版)
%D 2008
%I Science Press
%X Objective Recent studies reveal important roles of platelet P-seleetin on progression of atherosclerosis.In the present study,we examine the relation between Platelet P-selectin expression and severity of acute coronary syndromes.Methods One hundredand eighty-four consecutive patients with proven or clinically suspected acute coronary syndromes(ACS)were enrolled in the study.Level of P-selectin expression was determined bv flow cytometry.Platelet P-selectin level was expressed as the percentage of P-selectin positive platelet.Results The level of P-selectin was higher in patients with a single diseased coronary artery or multiplediseased arteries compared to thOSe with normal coronary arteries.P-selectin expression was significantly and positively correlatedwith angiographic Gensini score(r=0.323,P=0.029).Multiple regression analyses showed that the association of the percentage of P-selectin-positive platelets with ACS was independent of other clinical factors. Conclusions Platelet P-selectin is associated withseverity of acute coronary syndromes in patients with acute coronary syndromes.
%K platelets
%K P-selectin
%K acute coronary syndromes<br>
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=A9DB1C13C87CE289EA38239A9433C9DC&cid=AD36F34DDC3BA7B0&jid=4DC702B3A2386A4814E2FF9CFB799B27&aid=66EDE136485935ADA0671DBB0C170BDC&yid=67289AFF6305E306&vid=94C357A881DFC066&iid=38B194292C032A66&sid=A020552C37306588&eid=EB552E4CFC85690B&journal_id=1671-5411&journal_name=Journalofgeriatriccardiology:JGC&referenced_num=0&reference_num=22