%0 Journal Article
%T Effect of cyclosporine-A on electrophysiological properties of atria in tachycardia-induced atrial fibrillation<br>
%A Lei Gao
%A Wei Yan
%A Yuqi Liu
%A Ya Huang
%A Qi Chen
%A Yuxiao Zhang
%A Peng Liu
%A Caiyi Lu
%A <br>
%J 老年心脏病学杂志(英文版)
%D 2008
%I Science Press
%X Objective To investigate the effects of ciyelosporine-A(CsA).a calcinenrin(CAN)inhibitor,on electrophysiological propertiesof atria in canine tachycardia-induced model of AF.Methods Eighteen healthy adult mongrel canines weighing 17.0 to 23.2 kg(rangedfrom 2 to 4 years old)were randomized to 3 groups,Sham group(no pacemaker was implanted),atrial tachypacing group(ATP group)each group at baseline and after 8 weeks' tachypacing.Measurements included atrial effective refractory period(AERP),conductionvelocity(CV),wave length(WE),atrial fibrillation load and rate-adaptability. Results After 8 weeks' atrial tachypacing,ATP andCsA groups showed significant longer duration of the P wave,shorter AERP,decreased adaptation of AERE slower CV,shorter Wland longer AF duration compared to the shamg roup (all P＜0.05).AERP of the CsA group was longer than that of ATP group (P＜0.05),but there were no differences in rate-adaptability,CV,incidence of induced AF and AF duration between CsA group and ATP group.Conclusions Our results suggest that calcineurin pathway intervention by CsA have a positive effect on tachycardia-inducedelectrical remodeling of atria,but can not prevent or reverse AF.
%K attral fibrillation
%K calcineurin
%K CsA:electrophysiology
%K electrical remodeling<br>
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=A9DB1C13C87CE289EA38239A9433C9DC&cid=AD36F34DDC3BA7B0&jid=4DC702B3A2386A4814E2FF9CFB799B27&aid=7DD67FDD571909F6A5BEFD5C6F29A9FD&yid=67289AFF6305E306&vid=94C357A881DFC066&iid=38B194292C032A66&sid=A58CF3BAE79427D0&eid=4609832E4B5C797B&journal_id=1671-5411&journal_name=Journalofgeriatriccardiology:JGC&referenced_num=0&reference_num=15