%0 Journal Article
%T Calcineurin signalling mechanisms in myocardial hypertrophy<br>
%A Jian-Chun Wang
%A Yong Zhao
%A Jian-Hua Shao
%A <br>
%J 老年心脏病学杂志(英文版)
%D 2010
%I Science Press
%X Calcineurin dephosphorylates multiple serine residues near the N terminus of NFAT proteins enabling them to translocate from cytoplasm to nucleus, where they activate a subset of hypertrophic response genes. Transgenic mice over-expressing a constitutively active form of calcineurin or NFAT3, developed obviously hypertrophy and heart failure or sudden death proving its pathogenic role. Here we used literatures on MEDLINE (2000-2011), systematically reviewed the new development of calcineurin signaling pathway in myocardial hypertrophy (J Geriatr Cardiol 2010; 7:189-192).
%K Calcineurin
%K signal transduction
%K hypertrophy<br>
%U http://www.alljournals.cn/get_abstract_url.aspx?pcid=A9DB1C13C87CE289EA38239A9433C9DC&cid=AD36F34DDC3BA7B0&jid=4DC702B3A2386A4814E2FF9CFB799B27&aid=53D1930C2BB9CC715F72D374C1C82BBF&yid=140ECF96957D60B2&vid=DF92D298D3FF1E6E&iid=E158A972A605785F&sid=3A0155B37D8FF829&eid=C29816B2656377A7&journal_id=1671-5411&journal_name=Journalofgeriatriccardiology:JGC&referenced_num=0&reference_num=0