%0 Journal Article
%T Development of Membrane Selective Electrode for Determination of the Antipsychotic Sulpiride in Pharmaceuticals and Urine
%A Ma Soledad Garc¨ªa
%A Joaqu¨ªn A. Ortu£¿o
%A Ma Isabel Albero
%A Mustafa Salem Abuherba
%J Sensors
%D 2009
%I MDPI AG
%R 10.3390/s90604309
%X The construction and electrochemical response characteristics of a poly(vinyl chloride) (PVC) membrane selective electrode for the determination of sulpiride (SPD) are described. The sensing membrane comprised an ion-exchanger formed between the protonated drug and tetraphenylborate (TPB-) in a plasticized PVC matrix. The influence of membrane composition on the electrode response was studied. The electrode showed a fast, stable and Nernstian response over a sulpiride concentration range (1 ¡Á 10-4¨C 1 ¡Á 10-2 M) with a mean slope of 58.4 ¡À 0.9 mV dec-1 of concentration, a mean detection limit of 4.2 ¡Á 10-5 ¡À 1.2 ¡Á 10-5 M, a wide working pH range (2 ¨C 8) and a fast response time (< 15 s). The electrode showed good selectivity towards sulpiride with respect to some inorganic and organic compounds. When the electrode was applied to the determination of sulpiride in pharmaceuticals and human urine, a high percentage of recovery was attained with no need for sample pretreatment procedures because of the lack of interfering matrix effects.
%K ion-selective electrode
%K sulpiride determination
%K pharmaceuticals
%K urine
%U http://www.mdpi.com/1424-8220/9/6/4309